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Synthesis and mannosidase inhibitory activity of 6- and 7-substituted analogs of swainsonine

✍ Scribed by William H Pearson; Erik J Hembre

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 98 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01778-6

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✦ Synopsis

Swainsonine (1), an inhibitor of the important glycoprotein-processing enzyme Golgi a-mannosidase II, is a clinical candidate for cancer treatment. Analogs bearing substituents at C-6 and C-7 have been prepared and evaluated as inhibitors of a-mannosidase (jack bean), a closely related enzyme.

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