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Synthesis and mannosidase inhibitory activity of 3-benzyloxymethyl analogs of swainsonine

✍ Scribed by William H Pearson; Luyi Guo

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 98 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01777-4

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✦ Synopsis

Swainsonine (3), an inhibitor of Golgi a-mannosidase II, is a clinical candidate for cancer treatment. In order to avoid potential problems arising from its co-inhibition of lysosomal mannosidases, we have synthesized 3-benzyloxymethyl analogs of swainsonine (17 and 18). Initial screening of these new compounds is reported.

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