𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and Glycosidase Inhibitory Activity of 7-Deoxycasuarine

✍ Scribed by Ana T. Carmona; Richard H. Whigtman; Inmaculada Robina; Pierre Vogel

Publisher
John Wiley and Sons
Year
2003
Tongue
German
Weight
133 KB
Volume
86
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Reaction of 1,4‐anhydro‐2,3,5‐tri‐O‐benzyl‐1‐deoxy‐1‐imino‐D‐arabinitol N‐oxide (8) with allyl alcohol produced a 3.6 : 1 mixture of the two pyrrolo[1,2‐b]isoxazole derivatives 13 and 14. The major adduct 13 was converted to 7‐deoxycasuarine (7), a potent, specific, and competitive inhibitor of amyloglucosidase from Rhizopus mold (see Table).

📜 SIMILAR VOLUMES

Synthesis and inhibitory activity of gly
Synthesis and inhibitory activity of glycosidase inhibitors, glycosylamino-oxazolines
✍ Chikara Uchida; Seiichiro Ogawa 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 542 KB

In connection with structural modification of the trehalase inhibitor trehazolin (1), as a new-type of glycohydrolase inhibitor, some glycosylamino-oxazolines were designed and synthesized. Among three oxazolines beta-galacto (3), beta-gluco (5) and alpha-manno-types (6) obtained in stable form, the