Synthesis and Glycosidase Inhibitory Activity of 5a-Carba-α-DL-fucopyranosylamine and -galactopyranosylamine
✍ Scribed by Seiichiro Ogawa; Rieko Sekura; Ayako Maruyama; Hideya Yuasa; Hironobu Hashimoto
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 267 KB
- Volume
- 2000
- Category
- Article
- ISSN
- 1434-193X
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📜 SIMILAR VOLUMES
Carbohydrates / Cyclitols / Carba sugars / 5a-Carba-α--fucopyranosylamine / Enzyme inhibitors / α--Fucosidase inhibitors 5a-Carba-α-L-fucopyranosylamine ( ), an α-glucosidase inhibitor validamine analog possessing an α-L-fucose-type structure, and four related compounds (4 and 6-8) were synthesize
In order to elucidate the essential core structure of potent the five stereoisomers thus obtained for the six glycosidases has demonstrated the 2/3,4,5) and (1,2,3,4,5/0) isomers α-mannosidase inhibitors, e.g. mannostatin A, 5-amino-5-Cmethyl-1,2,3,4-cyclopentanetetrols 4-8 were designed and to be m
Three deoxy derivatives 2-4 of the α-mannosidase inhibitor mannostatin A (1) were synthesized, and their inhibition of Jack bean α-mannosidase was evaluated in order to elucidate the roles of each of the three hydroxyl groups of the inhibitor. The 1-and 2-deoxy derivatives 2 and 3 retained some