Synthesis and Biological Evaluation of α-L-Fucosidase Inhibitors: 5a-Carba-α-L-fucopyranosylamine and Related Compounds

✍ Scribed by Seiichiro Ogawa; Ayako Maruyama; Takashi Odagiri; Hideya Yuasa; Hironobu Hashimoto

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 399 KB
• Volume: 2001
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/1099-0690(200103)2001:5<967::aid-ejoc967>3.0.co;2-j

✦ Synopsis

Carbohydrates / Cyclitols / Carba sugars / 5a-Carba-α--fucopyranosylamine / Enzyme inhibitors / α--Fucosidase inhibitors 5a-Carba-α-L-fucopyranosylamine ( ), an α-glucosidase inhibitor validamine analog possessing an α-L-fucose-type structure, and four related compounds (4 and 6-8) were synthesized and their glycosidase