Synthesis and inhibitory activity of glycosidase inhibitors, glycosylamino-oxazolines

✍ Scribed by Chikara Uchida; Seiichiro Ogawa

• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 542 KB
• Volume: 4
• Category: Article
• ISSN: 0968-0896
• DOI: 10.1016/0968-0896(95)00181-6

✦ Synopsis

In connection with structural modification of the trehalase inhibitor trehazolin (1), as a new-type of glycohydrolase inhibitor, some glycosylamino-oxazolines were designed and synthesized. Among three oxazolines beta-galacto (3), beta-gluco (5) and alpha-manno-types (6) obtained in stable form, the latter 6 has been shown to possess a moderate inhibitory activity against alpha-mannosidase.