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Design, synthesis and biological evaluation of novel desmuramyldipeptide analogs

✍ Scribed by Žiga Jakopin; Emanuela Corsini; Martina Gobec; Irena Mlinarič-Raščan; Marija Sollner Dolenc

Book ID
113582979
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
721 KB
Volume
46
Category
Article
ISSN
0223-5234

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Synthesis and activity of phosphono desmuramyldipeptide analogs
✍ Uroš Urleb; Stanislav Gobec; Dušan Prelog 📂 Article 📅 1995 🏛 Springer Netherlands 🌐 English ⚖ 312 KB

Two phosphono desmuramyldipeptide analogs, 6 and 11, were synthesized and evaluated for immunomodulatory activity. Phthalimido-and adamantyl-substituted side chains as a replacement for the N-acetylmuraminic acid were coupled with appropriate dipeptides using DPPA as the coupling reagent. Introducti