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Synthesis of New 4,5‐Dihydro‐3(2 H )‐pyridazinone Derivatives

✍ Scribed by Meyer, E.; Joussef, A. C.; Gallardo, H.; de Souza, L. de B. P.


Book ID
118137385
Publisher
Taylor and Francis Group
Year
2004
Tongue
English
Weight
169 KB
Volume
34
Category
Article
ISSN
0039-7911

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✍ Carlos Alvarez-Ibarra; Aurelio G Csákÿ; Cristina Gómez de la Oliva; Eliazar Rodr 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 75 KB

The synthesis of optically pure 4,5-dihydro-3(2H)-pyridazinones substituted at C-4, which can be considered conformationally restricted cyclic Glu derivatives, has been accomplished by the asymmetric g-alkylation of a,b-unsaturated glutamyl sultams under PTC conditions followed by reaction with hydr