Conformationally restricted glutamic acid derivatives: asymmetric synthesis of 4-substituted 4,5-dihydro-3(2H)-pyridazinones

✍ Scribed by Carlos Alvarez-Ibarra; Aurelio G Csákÿ; Cristina Gómez de la Oliva; Eliazar Rodrı́guez

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 75 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00147-2

✦ Synopsis

The synthesis of optically pure 4,5-dihydro-3(2H)-pyridazinones substituted at C-4, which can be considered conformationally restricted cyclic Glu derivatives, has been accomplished by the asymmetric g-alkylation of a,b-unsaturated glutamyl sultams under PTC conditions followed by reaction with hydrazines.