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An Efficient Synthesis of 4,5-Dihydro-3(2H)-pyridazinone Derivatives

✍ Scribed by Tóth, György; Molnár, Sándor; Tamás, Tivadar; Borbély, Ildikó


Book ID
115522568
Publisher
Taylor and Francis Group
Year
1997
Tongue
English
Weight
322 KB
Volume
27
Category
Article
ISSN
0039-7911

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Conformationally restricted glutamic aci
✍ Carlos Alvarez-Ibarra; Aurelio G Csákÿ; Cristina Gómez de la Oliva; Eliazar Rodr 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 75 KB

The synthesis of optically pure 4,5-dihydro-3(2H)-pyridazinones substituted at C-4, which can be considered conformationally restricted cyclic Glu derivatives, has been accomplished by the asymmetric g-alkylation of a,b-unsaturated glutamyl sultams under PTC conditions followed by reaction with hydr