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Synthesis of 6-substituted-4,5-dihydro-3(2H)-pyridazinones

✍ Scribed by P. G. Baraldi; A. Chiarini; A. Leoni; S. Manfredini; D. Simoni; V. Zanirato


Book ID
112129559
Publisher
Journal of Heterocyclic Chemistry
Year
1990
Tongue
English
Weight
231 KB
Volume
27
Category
Article
ISSN
0022-152X

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Conformationally restricted glutamic aci
✍ Carlos Alvarez-Ibarra; Aurelio G CsΓ‘kΓΏ; Cristina GΓ³mez de la Oliva; Eliazar Rodr πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 75 KB

The synthesis of optically pure 4,5-dihydro-3(2H)-pyridazinones substituted at C-4, which can be considered conformationally restricted cyclic Glu derivatives, has been accomplished by the asymmetric g-alkylation of a,b-unsaturated glutamyl sultams under PTC conditions followed by reaction with hydr