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Synthesis of nectrisine and related compounds, and their biological evaluation

✍ Scribed by Yong Jip Kim; Akira Takatsuki; Naoto Kogoshi; Takeshi Kitahara

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 702 KB
Volume: 55
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(99)00459-7

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✦ Synopsis

An efficient and novel process is described for the synthesis of nectrisine 5 and its related derivatives 6,'/as potent glucosidase inhibitors via the corresponding lactams starting from D-(-)-diethyl tara'ate. Also the results of biological evaluation of the synthesized compounds are described.

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