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Synthesis and biological evaluation of flavonoids and related compounds as gastroprotective agents

โœ Scribed by Jeffrey J. Ares; Pamela E. Outt; Jared L. Randall; Jeffrey N. Johnston; Peter D. Murray; Linda M. O'Brien; Pamela S. Weisshaar; Beth L. Ems

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
208 KB
Volume
6
Category
Article
ISSN
0960-894X

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โœฆ Synopsis

Several analogs of the gastroprotective molecule flavone have been synthesized and evaluated for gastroprotective activity. A C2-C3 double bond and an intact C ring appear necessary for optimum activity. Activity can be retained by replacing the 2-phenyl substituent with other groups but is eliminated when this ring is moved from the 2-to the 3-position.

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