Synthesis of Natural Products and Related Compounds using Enyne Metathesis
✍ Scribed by Miwako Mori
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 363 KB
- Volume
- 349
- Category
- Article
- ISSN
- 1615-4150
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📜 SIMILAR VOLUMES
New synthetic routes to chiral polyhydrox lated aldehydes from lower terms employing 2-substituted thiazoles as homologating reagents are descrited. In all cases the thiazole ring serves as a convenient formyl group equivalent.
The stereoselective synthesis of the naturally occurring lactones osmundalactone (-)-1 and muricatacin (-)-2 is described. The key steps in each synthesis are the stereoselective addition of a Grignard reagent to a suitably protected αhydroxy aldehyde and a ring-closing metathesis.
The structure of the metathesis catalyst 10 depicted in Scheme 2 on page 2650 is not correct; instead, it should read PhCHϭRuCl 2 (PCy 3 ) 2 (Cy ϭ cyclohexyl).