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Macrocyclization by Ring-Closing Metathesis in the Total Synthesis of Natural Products: Reaction Conditions and Limitations

✍ Scribed by Ana Gradillas; Javier Pérez-Castells


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
37 KB
Volume
45
Category
Article
ISSN
0044-8249

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Synthesis Mediated by Ring-Closing Metat
✍ Upendra K. Pandit; Herman S. Overkleeft; Bennett C. Borer; Hans Bieräugel 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 440 KB 👁 2 views

The application of the ring-closing metathesis (RCM) castanospermine ( ) is presented. The utilisation of two RCM steps in the synthetic sequence leading to the multicyclic reaction to the construction of a wide variety of nitrogencontaining ring systems is described. The examples include ABCDE nucl