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Synthesis Mediated by Ring-Closing Metathesis – Applications in the Synthesis of Azasugars and Alkaloids

✍ Scribed by Upendra K. Pandit; Herman S. Overkleeft; Bennett C. Borer; Hans Bieräugel

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
440 KB
Volume
1999
Category
Article
ISSN
1434-193X

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✦ Synopsis

The application of the ring-closing metathesis (RCM) castanospermine ( ) is presented. The utilisation of two RCM steps in the synthetic sequence leading to the multicyclic reaction to the construction of a wide variety of nitrogencontaining ring systems is described. The examples include ABCDE nucleus 7 of the complex alkaloid manzamine A ( ) is discussed. pyrrolizidine, indolizidine, and quinolizidine derivatives related to azasugars. A formal total synthesis of MICROREVIEWS: This feature introduces the readers to the authors' research through a concise overview of the selected topic. Reference to important work from others in the field is included.

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