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Stereoselective Synthesis of the Naturally Occurring Lactones (−)-Osmundalactone and (−)-Muricatacine Using Ring-Closing Metathesis

✍ Scribed by Miguel Carda; Santiago Rodríguez; Florenci González; Encarnación Castillo; Alicia Villanueva; J. Alberto Marco

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
150 KB
Volume
2002
Category
Article
ISSN
1434-193X

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✦ Synopsis

The stereoselective synthesis of the naturally occurring lactones osmundalactone (-)-1 and muricatacin (-)-2 is described. The key steps in each synthesis are the stereoselective addition of a Grignard reagent to a suitably protected αhydroxy aldehyde and a ring-closing metathesis.

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Stereoselective Synthesis of the Natural
Stereoselective Synthesis of the Naturally Occurring Lactones(−)-Osmundalactone and (−)-Muricatacine Using Ring-Closing Metathesis
✍ Miguel Carda; Santiago Rodríguez; Florenci González; Encarnación Castillo; Alici 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 27 KB 👁 1 views

The structure of the metathesis catalyst 10 depicted in Scheme 2 on page 2650 is not correct; instead, it should read PhCHϭRuCl 2 (PCy 3 ) 2 (Cy ϭ cyclohexyl).