Synthesis of N-homobicyclic dideoxynucleoside analogues
β Scribed by N. Raghavendra Swamy; N. Suryakiran; P. Paradesi Naidu; Y. Venkateswarlu
- Book ID
- 113515495
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 448 KB
- Volume
- 352
- Category
- Article
- ISSN
- 0008-6215
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π SIMILAR VOLUMES
The synthesis IS described of the fmt members of a new class of nucleoside analogues m winch the tetrahydrofuran ring is replaced by a pyrrohdine nng hnked to the base through an N-N bond the pyrrolidinyl analogues of 2',3'-hdeoxycyttdme (lo), unclme (S), and thymldme (9) were prepared via construct
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N-Tritylated l-and d-methionine and l-glutamic acid were used to obtain novel chiral iso-dideoxynucleoside analogues incorporating a tetrahydrofuranyl or a tetrahyropyranyl ring as the pseudosugar part, and at positions 2 and 3 of the ring an hydroxyethyl group and thymine or adenine, respectively.