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Total syntheses of novel dideoxynucleoside analogues using chiral amino acids

✍ Scribed by George Balayiannis; George Karigiannis; Panayiotis Gatos; Dionissios Papaioannou; Erik De Clercq

Book ID: 104210632
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 163 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01004-2

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✦ Synopsis

N-Tritylated l-and d-methionine and l-glutamic acid were used to obtain novel chiral iso-dideoxynucleoside analogues incorporating a tetrahydrofuranyl or a tetrahyropyranyl ring as the pseudosugar part, and at positions 2 and 3 of the ring an hydroxyethyl group and thymine or adenine, respectively.

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