Convenient Synthesis of C-Aza-2,3-dideoxynucleosides. -With a view to their interesting biological activity the synthesis of the title nucleosides such as (VII) is performed. The structure (VIId) is determined by X-ray analysis. Some of the compounds show modest anti-HIV activity. -(MO-
ChemInform Abstract: Diastereoselective and Enantioselective Synthesis of 4′-Aza Analogues of 2′,3′-Dideoxynucleosides.
✍ Scribed by Ugo Chiacchio; Antonio Rescifina; Antonio Corsaro; Venerando Pistara; Giovanni Romeo; Roberto Romeo
- Publisher
- John Wiley and Sons
- Year
- 2000
- Weight
- 30 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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📜 SIMILAR VOLUMES
A Novel Class of 4'-Aza Analogues of 2',3'-Dideoxynucleosides as Potential anti-HIV Drugs. -The novel isoxazoline nucleoside (VI) (no yield given) is prepared by 1,3-dipolar cycloaddition of a nitrone to vinyladenine (III).