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Synthesis of pyrrolidin-1-yl analogues of pyrimidine dideoxynucleosides

✍ Scribed by Michael R. Harnden; Richard L. Jarvest

Book ID: 104215979
Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 267 KB
Volume: 32
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)79398-1

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✦ Synopsis

The synthesis IS described of the fmt members of a new class of nucleoside analogues m winch the tetrahydrofuran ring is replaced by a pyrrohdine nng hnked to the base through an N-N bond the pyrrolidinyl analogues of 2',3'-hdeoxycyttdme (lo), unclme (S), and thymldme (9) were prepared via construction of the base on a 1-aminopynohdme (15).

A number of molecular targets have been identified for strategies to inhibit the replication of HIV, the causative agent of AIDS, and of these the most successfully exploited so far is the virally encoded reverse transcnptase.

The 2',3'-dideoxynucleosides

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