Synthesis of N-formyl- and N-succinyl-D-neuraminic acid on the specificity of neuraminidase
โ Scribed by R. Brossmer; E. Nebelin
- Book ID
- 115901095
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- English
- Weight
- 170 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0014-5793
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๐ SIMILAR VOLUMES
N-Acetylneuraminic acid (1) can be transformed into the methyl a-u-ketoside 2 which, by reaction with methanesulfonyl chloride, yields the corresponding 4-0 mesylate 3 and the 4.7-di-0 -mesylate 4 as a by-product. Compound 3 reacts with Nal giving the 4-dcoxy-4-iodo compound 5 with cquatorial orient
Aldol condensation of la with potassium di-tert-butyloxaloacetate yields the two epimeric 6-thiosialic acids 2 and 3. As opposed to this, reaction between thiofuranose 6 \_ and nickel (II)/oxaloacetate affords 6-thio-N-acetyl-D-neuraminic acid \_Ic. Substituting sulfur for oxygen in the pyranosering
much more slowly than would be expected according t o theory. The reason is that the growth of crystalline precipitates at concentrations close to saturation is generally not diffusion-controlled. A third example is the kinetics of phase separation in quenched supersaturated metal alloys, such as Ag