The Synthesis of N-Glycolylneuraminic Acid and the Biochemistry of Glycoproteins Containing Neuraminic Acid
โ Scribed by H. Faillard
- Publisher
- John Wiley and Sons
- Year
- 1965
- Tongue
- English
- Weight
- 258 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0044-8249
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โฆ Synopsis
much more slowly than would be expected according t o theory. The reason is that the growth of crystalline precipitates at concentrations close to saturation is generally not diffusion-controlled. A third example is the kinetics of phase separation in quenched supersaturated metal alloys, such as Ag-Pb. An interpretation of this separation as ripening of the clusters formed on quenching is suggested. The change in particle number and size may be traced by resistance measurements and with an electron microscope. Measurements have so far shown qualitative agreement with theory. Independent measurements of the diffusion coefficient in heterogeneous crystals are necessary, however, for reliable evaluation, especially with regard to a calculation of the interfacial tension between two solid phases. [GDCh-Ortsverband Gottingen (Germany), December I7th, 19641 [VB 8991204 IE]
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V = 1078.3(5) x lo6 pm3, psalsd = 1.089 g ~m -~, Z = 2, crystal size 0.3 x 0.3 x 0.9 mm3, 173 K, Cu,,, radiation, Enraf-Nonius CAD4, scan width 2.25 <8 < 76.5",4202 symmetry-independent and significant reflections [IF1 >3u(F)] structure solution by direct methods (SHELXS-86 [6]) supplemented by diff
Integration between the alkaline epimerization of N-acetyl-D-glucosamine (GlcNAc) to N-Acetyl-Dmannosamine (ManNAc) and the N-acetyl-D-neuraminic acid (Neu5Ac) aldolase-catalyzed biotransformation has been assessed experimentally. GlcNAc epimerization took place above pH 9.0, and the initial rate of