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Synthesis of N-Alkylated and N-Arylated Derivatives of 2-Amino-2‘-hydroxy-1,1‘-binaphthyl (NOBIN) and 2,2‘-Diamino-1,1‘-binaphthyl and Their Application in the Enantioselective Addition of Diethylzinc to Aromatic Aldehydes†

✍ Scribed by Vyskočil, Štěpán; Jaracz, Stanislav; Smrčina, Martin; Štícha, Martin; Hanuš, Vladimír; Polášek, Miroslav; Kočovský, Pavel


Book ID
111878215
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
157 KB
Volume
63
Category
Article
ISSN
0022-3263

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Preparation of 2-amino-2′-hydroxy-1,1′-b
✍ Robert A. Singer; Stephen L. Buchwald 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 280 KB

Palladium-catalyzed amination reactions were carried out with 2-triflato-2'-(4methoxybenzyloxy)-1,1'-binaphthyl (5) and benzophenone imine followed by hydrolysis of the imine and hydrogenolysis of the benzyl protecting group to afford 2-amino-2'-hydroxy-1,1'binaphthyl (1). Arylamines were also coupl