ChemInform Abstract: Preparation of 2-Amino-2′-hydroxy-1,1′-binaphthyl and N-Arylated 2-Amino-1,1′-binaphthyl Derivatives via Palladium-Catalyzed Amination.
✍ Scribed by Robert A. Singer; Stephen L. Buchwald
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 31 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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Derivatives of 2-Amino-2'-diphenylphosphino-1,1'-binaphthyl (MAP) and Their Application in Asymmetric Palladium(0)-Catalyzed Allylic Substitution. -The novel chiral biaryls (I), readily synthesized from the corresponding N-unsubstituted optically active precursor, are utilized as chiral ligands in
Synthesis of 2-Amino-2'-diphenylphosphino-1,1'-binaphthyl (MAP) and Its Accelerating Effect on the Pd(0)-Catalyzed N-Arylation. -The title compound (R)-(I), available from (R)-(II) in four steps, is found to exhibit an accelerating effect on the Pd-catalyzed Hartwig-Buchwald N-phenylation of racemi