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Preparation of 2-amino-2′-hydroxy-1,1′-binaphthyl and N-arylated 2-amino-1,1′-binaphthyl derivatives via palladium-catalyzed amination

✍ Scribed by Robert A. Singer; Stephen L. Buchwald

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 280 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)02642-2

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✦ Synopsis

Palladium-catalyzed amination reactions were carried out with 2-triflato-2'-(4methoxybenzyloxy)-1,1'-binaphthyl (5) and benzophenone imine followed by hydrolysis of the imine and hydrogenolysis of the benzyl protecting group to afford 2-amino-2'-hydroxy-1,1'binaphthyl (1). Arylamines were also coupled successfully with 5 under similar conditions.

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