Palladium-catalyzed amination reactions were carried out with 2-triflato-2'-(4methoxybenzyloxy)-1,1'-binaphthyl (5) and benzophenone imine followed by hydrolysis of the imine and hydrogenolysis of the benzyl protecting group to afford 2-amino-2'-hydroxy-1,1'binaphthyl (1). Arylamines were also coupl
✦ LIBER ✦
A practical synthesis of 2-amino-2′-hydroxy-1,1′-binaphthyl (NOBIN)
✍ Scribed by Karsten Körber; Wenjun Tang; Xinquan Hu; Xumu Zhang
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 92 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
A practical synthesis of 2-amino-2%-hydroxy-1,1%-binaphthyl (NOBIN) was realized from BINOL through a single step. Its facile purification procedure makes the process amenable for large scale synthesis of NOBIN.
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