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Synthesis of N-acetyl-β-D-glucosaminyl-(1-4)-N-acetylmuramyl- L -alanyl-D-isoglutamine

✍ Scribed by Shoichi Kusumoto; Koji Yamamoto; Tetsuo Shiba

Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
273 KB
Volume
19
Category
Article
ISSN
0040-4039

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✦ Synopsis

Our synthetic studies on muramyl peptides have significantly elucidated the relationship between the immunoadjuvant activity and the chemical structure. 2)

📜 SIMILAR VOLUMES

Bacterial cell wall constituents. II.1 s
Bacterial cell wall constituents. II.1 synthesis of O-(N-acetyl-β-muramyl-L-alanyl-D-isoglutamine)-(1→4)-N-acetyl-D-glucosamine
✍ Philippe L. Durette; Eric P. Meitzner; T.Y. Shen 📂 Article 📅 1979 🏛 Elsevier Science 🌐 French ⚖ 228 KB

O-(N-Acetyl-~-muramyl-L-alanyl-D\_isoglutamine)-(1~4)-~-acetyl-D-glucosamine (3, the re--peating disaccharide dipeptTde unit %tained by endo-&acetylglucos%minidase lysis of bacterial cell walls, has been synthesized in a twelve-step sequence from g-acetyl-g-glucosamine.

Synthesis of (N-acetyl-1-O-acylmuramoyl)
Synthesis of (N-acetyl-1-O-acylmuramoyl)-l-alanyl-d-isoglutamines, and their immunoadjuvant activities
✍ Akira Hasegawa; Yuichi Hioki; Makoto Kiso; Ichiro Azuma 📂 Article 📅 1983 🏛 Elsevier Science 🌐 English ⚖ 476 KB

I-0-Acyl derivatives of N-acetylmuramoyl-I.-alanyl-n-isogtutaminc (MDP) have been synthesized from 2-acctamido-l-O-bcnzoyl-4.6-O-isopropylidenc-3-0-[D-I-(methoxycarbonyI)ethyl]-e-D-glucopyranose. Their immunoadjuvant activities were examined in guinea-pigs. (N-ACETYL-I -0-ACYLMURAMOYI.).L-AI.ANYI.-