✦ LIBER ✦

Synthesis of (N-acetyl-1-O-acylmuramoyl)-l-alanyl-d-isoglutamines, and their immunoadjuvant activities

✍ Scribed by Akira Hasegawa; Yuichi Hioki; Makoto Kiso; Ichiro Azuma

Publisher: Elsevier Science
Year: 1983
Tongue: English
Weight: 476 KB
Volume: 123
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(83)88381-5

No coin nor oath required. For personal study only.

✦ Synopsis

I-0-Acyl derivatives of N-acetylmuramoyl-I.-alanyl-n-isogtutaminc (MDP) have been synthesized from 2-acctamido-l-O-bcnzoyl-4.6-O-isopropylidenc-3-0-[D-I-(methoxycarbonyI)ethyl]-e-D-glucopyranose. Their immunoadjuvant activities were examined in guinea-pigs.

(N-ACETYL-I -0-ACYLMURAMOYI.).L-AI.ANYI.-I)-TSOGI.UTAMINES 71 methylene), 1730 and 1260 (ester), 1710 (C=O), and 1650 and 1530 cm-' (amide).

📜 SIMILAR VOLUMES

Synthesis of 6-o-mycoloyl-n-acetylmuramy

Synthesis of 6-o-mycoloyl-n-acetylmuramyl-l-alanyl- D-isoglutamine with immunoadjuvant activity

✍ Shoichi Kusumoto; Satoshi Okada; Tetsuo Shiba; Ichiro Azuma; Yuichi Yamamura 📂 Article 📅 1976 🏛 Elsevier Science 🌐 French ⚖ 224 KB

Synthesis of N-acetyl-β-D-glucosaminyl-(

Synthesis of N-acetyl-β-D-glucosaminyl-(1-4)-N-acetylmuramyl- L -alanyl-D-isoglutamine

✍ Shoichi Kusumoto; Koji Yamamoto; Tetsuo Shiba 📂 Article 📅 1978 🏛 Elsevier Science 🌐 French ⚖ 273 KB

Our synthetic studies on muramyl peptides have significantly elucidated the relationship between the immunoadjuvant activity and the chemical structure. 2)

Synthesis of 4-o-(N-acetyl-β-D-glucosami

Synthesis of 4-o-(N-acetyl-β-D-glucosaminyl)-6-o-acyl-N-acetylmuramyl-L-alanyl-D-isoglutamine

✍ Masaru Inage; Masahiro Imoto; Yoshikazu Kambayashi; Shoichi Kusumoto; Tetsuo Shi 📂 Article 📅 1980 🏛 Elsevier Science 🌐 French ⚖ 219 KB

Bacterial cell wall constituents. II.1 s

Bacterial cell wall constituents. II.1 synthesis of O-(N-acetyl-β-muramyl-L-alanyl-D-isoglutamine)-(1→4)-N-acetyl-D-glucosamine

✍ Philippe L. Durette; Eric P. Meitzner; T.Y. Shen 📂 Article 📅 1979 🏛 Elsevier Science 🌐 French ⚖ 228 KB

O-(N-Acetyl-~-muramyl-L-alanyl-D\_isoglutamine)-(1~4)-~-acetyl-D-glucosamine (3, the re--peating disaccharide dipeptTde unit %tained by endo-&acetylglucos%minidase lysis of bacterial cell walls, has been synthesized in a twelve-step sequence from g-acetyl-g-glucosamine.

Synthesis and biological activities of N

Synthesis and biological activities of N-acetyl-1-thiomuramoyl-l-alanyl-d-isoglutamine and some of its lipophilic derivatives

✍ Akira Hasegawa; Yuichi Hioki; Makoto Kiso; Hiroyuki Okumura; Ichiro Azuma 📂 Article 📅 1983 🏛 Elsevier Science 🌐 English ⚖ 995 KB

N-Acetyl-1-thiomuramoyl-L-alanyl-D-isoglutamine and some lipophilic analogs were synthesized from benzyl 2-acetamido-2-deoxy-4,6-O-isopropylidene-3-O-[D-1-(methoxycarbonyl)ethyl ]- alpha-D-glucopyranoside (1). O-Debenzoylation of 2, derived from 1 by oxidation, gave 2-acetamido-2-deoxy-4,6-O-isoprop

Synthesis and Spectroscopic Characteriza

Synthesis and Spectroscopic Characterization of N2-(N-Acetyl-6-O-stearoyl-α-D-muramoyl)-L-alanyl-D-isoglutamine

✍ Fritz Dick; Titus A. Jenny 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 German ⚖ 402 KB 👁 1 views

Title compound 1 was synthesized by a published route which had to be modified (seven steps from readily obtainable starting materials). Characterization of 1 was achieved by spectroscopic means (FAB-MS, ' H-NMR, including 2D-COSY). Furthermore, commercially available reference material purchased fo