I-0-Acyl derivatives of N-acetylmuramoyl-I.-alanyl-n-isogtutaminc (MDP) have been synthesized from 2-acctamido-l-O-bcnzoyl-4.6-O-isopropylidenc-3-0-[D-I-(methoxycarbonyI)ethyl]-e-D-glucopyranose. Their immunoadjuvant activities were examined in guinea-pigs. (N-ACETYL-I -0-ACYLMURAMOYI.).L-AI.ANYI.-
Synthesis of 6-o-mycoloyl-n-acetylmuramyl-l-alanyl- D-isoglutamine with immunoadjuvant activity
โ Scribed by Shoichi Kusumoto; Satoshi Okada; Tetsuo Shiba; Ichiro Azuma; Yuichi Yamamura
- Publisher
- Elsevier Science
- Year
- 1976
- Tongue
- French
- Weight
- 224 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
Our synthetic studies on muramyl peptides have significantly elucidated the relationship between the immunoadjuvant activity and the chemical structure. 2)
Our synthetic study revealed that N-acetylmuramyl-L-alanyl-D-isoglutamine (l\_) is the minimum effective structure required for the immuno potentiating ability of various bacterial cell walls. However, the muramyl dipeptide (1) showed no antitumor activity based on immuno reaction, whereas cell wall
In our continuing efforts to elucidate the relationships between the biological activities of iv-acetylmuramoyl-L-alanyl-D-isoglutamine\*\* (MDP) and the structure of the carbohydrate moiety, and to obtain glycopeptide adjuvants that exhibit strong activity and lower toxicity, it was demonstrated th