Our synthetic studies on muramyl peptides have significantly elucidated the relationship between the immunoadjuvant activity and the chemical structure. 2)
Synthesis of 4-o-(N-acetyl-β-D-glucosaminyl)-6-o-acyl-N-acetylmuramyl-L-alanyl-D-isoglutamine
✍ Scribed by Masaru Inage; Masahiro Imoto; Yoshikazu Kambayashi; Shoichi Kusumoto; Tetsuo Shiba
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- French
- Weight
- 219 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
O-(N-Acetyl-~-muramyl-L-alanyl-D\_isoglutamine)-(1~4)-~-acetyl-D-glucosamine (3, the re--peating disaccharide dipeptTde unit %tained by endo-&acetylglucos%minidase lysis of bacterial cell walls, has been synthesized in a twelve-step sequence from g-acetyl-g-glucosamine.
Title compound 1 was synthesized by a published route which had to be modified (seven steps from readily obtainable starting materials). Characterization of 1 was achieved by spectroscopic means (FAB-MS, ' H-NMR, including 2D-COSY). Furthermore, commercially available reference material purchased fo
I-0-Acyl derivatives of N-acetylmuramoyl-I.-alanyl-n-isogtutaminc (MDP) have been synthesized from 2-acctamido-l-O-bcnzoyl-4.6-O-isopropylidenc-3-0-[D-I-(methoxycarbonyI)ethyl]-e-D-glucopyranose. Their immunoadjuvant activities were examined in guinea-pigs. (N-ACETYL-I -0-ACYLMURAMOYI.).L-AI.ANYI.-