Synthesis of N-(1-naphthyl) hydroxamic acids
β Scribed by Mudaliar, Anuradha; Agrawal, Yadvendra K.
- Book ID
- 118160144
- Publisher
- American Chemical Society
- Year
- 1979
- Tongue
- English
- Weight
- 221 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0021-9568
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π SIMILAR VOLUMES
A novel approach to the solid supported synthesis of hydroxamic acids was developed. It employs oxime resin and unlike all previously reported methods allows for the use of acid labile protecting groups. Cleavage is induced by treatment with tert-butyldimethylsilyl-O-hydroxylamine, followed by silyl
## Abstrrrct: lk nitroacetyl (S)-proline esfers (Z,3,.5} are reduced by zinc-NH,Cl to the hydroxylamine stage and cyclized toprovide the novel chit-al bicyclic hydroxamic acids (2,4,6). Michael addition of ally1 acrylate on nhmacetic acid derivatives followed by Pd(0) catalyzed intramolecular ally1