Synthesis of glucosaminoglycans hydroxamic acids
✍ Scribed by I. Yu. Ponedel’kina,A. R. Gaskarova,E. S. Lukina…
- Book ID
- 118298429
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 59 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0009-3130
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📜 SIMILAR VOLUMES
A novel approach to the solid supported synthesis of hydroxamic acids was developed. It employs oxime resin and unlike all previously reported methods allows for the use of acid labile protecting groups. Cleavage is induced by treatment with tert-butyldimethylsilyl-O-hydroxylamine, followed by silyl
## Abstrrrct: lk nitroacetyl (S)-proline esfers (Z,3,.5} are reduced by zinc-NH,Cl to the hydroxylamine stage and cyclized toprovide the novel chit-al bicyclic hydroxamic acids (2,4,6). Michael addition of ally1 acrylate on nhmacetic acid derivatives followed by Pd(0) catalyzed intramolecular ally1
The synthesis of peptide hydroxamic acids has been performed on a solid support. A carboxyl group of a peptide synthesized on/xTa-methylbenzhydrylamin¢ (pMBHA) resin was converted to a hydroxamate functional group by condensing with NH2OBzl, which was found preferable to NH2OtBu or NH2OTrt. The hydr