## Abstract 2,3‐Dihydroxybenzoic acid‐(carboxyl‐^14^C) can be synthesized in high overall yield from commercially‐available 2,3‐dimethoxybenzoic acid. The synthetic route features the application of a Curtius rearrangement, the thermal decomposition of a carboxylic acid azide to an isocyanate. The
Synthesis of microamounts of ketones from carboxylic acids: 1-phenoxy-2-butanones-2-14-14C
✍ Scribed by Melvin Look
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- French
- Weight
- 90 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
A technique using acetic acid as a co‐reactant for synthesizing microamounts of radiolabelled ketones from carboxylic acids with ethyl lithium is described. The acetic acid forms methyl ethyl ketone, a compound easily separated from the radiolabelled products.
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## Abstract [1‐^14^C]‐2,2‐Difluoroethene was synthesized from [^14^C]‐formaldehyde using a modification of the Wadsworth‐Emmons reaction, __via__ formation of the intermediate (EtO)~2~P(O)CF~2~^14^CH~2~OSiMe~3~. This highly volatile product was collected in a liquid nitrogen trap at a purity of >97
## Abstract A versatile method for ^14^C labeling of 2‐methoxypyrimidine‐5‐carboxylic acid at the 2‐position has been developed after encountering difficulties with traditional approaches to label the carboxyl function. The method developed can also be used for ^14^C labeling other positions of the
## Abstract A growing interest in the phytotoxic effects of trichloroacetic acid (TCA) has led us to develop a small‐scale (<1 mmol) one‐pot synthesis of [1,2‐^14^C]TCA with >70% yield and specific activity of 3.7 GBq/mmol. Copyright © 2001 John Wiley & Sons, Ltd.