Condensation of guanidine-15N3 with 4-[ N( 2-amino-3-cyano-5-pyrazinylmethyl)-N-methylamino] benzoic acid (1) in refluxing methanol afforded 4amino-4-deoxy-N10-methylpteroic-3-15N-2-15NH2 (2). indicated no label introduction at the pterin N1 position. Coupling of 2. with diethyl L-gluatmate and subs
Synthesis of methotrexate-1-15N and methotrexate-4-15NH2
β Scribed by Joseph I. Degraw; Kenneth J. Ryan; Michael Tracy; William T. Colwell; John R. P. Arnold; Gordon C. K. Roberts
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 391 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0022-2135
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