𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of methotrexate-1-15N and methotrexate-4-15NH2

✍ Scribed by Joseph I. Degraw; Kenneth J. Ryan; Michael Tracy; William T. Colwell; John R. P. Arnold; Gordon C. K. Roberts


Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
391 KB
Volume
27
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Synthesis of methotrexate-3-15N-2-15NH2.
✍ Joseph I. Degraw; Kenneth J. Ryan; William T. Colwell; John R. P. Arnold; Gordon πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 French βš– 205 KB πŸ‘ 1 views

Condensation of guanidine-15N3 with 4-[ N( 2-amino-3-cyano-5-pyrazinylmethyl)-N-methylamino] benzoic acid (1) in refluxing methanol afforded 4amino-4-deoxy-N10-methylpteroic-3-15N-2-15NH2 (2). indicated no label introduction at the pterin N1 position. Coupling of 2. with diethyl L-gluatmate and subs

Syntheses of [1-15N]-2β€²-Deoxyinosine, [4
✍ Bruno Catalanotti; Lorenzo De Napoli; Aldo Galeone; Luciano Mayol; Giorgia Olivi πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 158 KB πŸ‘ 4 views

A high-yield synthesis of [1-15 N]-2Ј-deoxyinosine ( 5), [4-counterpart, through [1-15 N]-2Ј-deoxyinosine (5), and successively, [4-15 N]-2Ј-deoxyAICAR ( 7). [1-15 N]-2Ј-15 N]-2Ј-deoxyAICAR (7), and [1-15 N]-2Ј-deoxyguanosine (10) from 2Ј-deoxyinosine (1) using relatively low expensive Deoxyguanosi

Synthesis of 15N labelledl alkaloids: Co
✍ E. Leete; H. V. Isaacson; H. D. Durst πŸ“‚ Article πŸ“… 1971 πŸ› John Wiley and Sons 🌐 French βš– 252 KB

Coniine-15N was obtained by the reductive amination of 5-0x0octanal using sodium cyanoborohydride and a m m o n i ~m -~~N bromide. Nornicotine-l'-15N resulted from a similar reductive aminution of 4-oxo-4-(3'-pyridyl)butanal. Merhybtion with formaldehyde and ,formic acid afforded n i ~o t i n e -I '