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Synthesis of Melithiazol B and Related Compounds via Oxidative Degradation of Myxothiazol A and Z

✍ Scribed by Udo Söker; Florenz Sasse; Brigitte Kunze; Gerhard Höfle

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
248 KB
Volume
2000
Category
Article
ISSN
1434-193X

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✦ Synopsis

The synthesis of melithiazol B (4) has been accomplished in five steps and 19% overall yield starting from myxothiazol A (1). Key steps include the conversion of the amide into the methyl ester 4, oxygenation to hydroperoxides 7 and 9, and

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