The synthesis of melithiazol B (4) has been accomplished in five steps and 19% overall yield starting from myxothiazol A (1). Key steps include the conversion of the amide into the methyl ester 4, oxygenation to hydroperoxides 7 and 9, and
✦ LIBER ✦
Synthesis of Diindenyldivanadium—a New Variant of the Reductive Degradation of Metallocenes and Related Compounds
✍ Scribed by Prof. Dr. Klaus Jonas; Dipl.-Chem. Wolfgang Rüsseler; Prof. Dr. Carl Krüger; Dr. Eleonore Raabe
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 277 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0044-8249
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m. p.=248-250GC (dec.; from methanol); [.ID= -129.' (DMSO, c = 1.00); 'H-NMR (D6-DMSO); t=4.13 and 4.18 (s, I-H+l'-H and s, 2 2-benzyl-H, or vice versa); MS: 520 (M+)]. The amino ketone ( 8 ) is probably first formed, being later aromatized by dimerization and air oxidation to yield ( 9 ) . The firs