Synthesis and Pharmacological Study of a Thiophene Analogue of Moprolol and Related Compounds

✍ Scribed by M. B. El-Ashmawy; J. Lissavetzky; V. Darias; D. Martín-Herrera

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 302 KB
• Volume: 324
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.19913240112

✦ Synopsis

The syntheses of the thiophenic analogue of Moprolol (Id) and of its related compound l a are described. From a preliminary pharmacological evaluation compound Id seems worthy of further studies due to its notable P-blocking activity and its remarkable anti-platelet aggregation action.

Synthese und pharmakologische

Untersuchung eines Thiophen-Analogen von Moprolol und venvandter Verbindungen Die Synthese des Thiophenisosters Id des Moprolols und der verwandten Verbindung la wird beschrieben. Aus einer vorlaufigen phakologischen Untersuchung geht hervor, da6 Id wegen seiner P-Rezeptoren blockierenden Wirkung und seiner beachtenswerten antiagpgatorischen Eigenschaften weiter untersucht werden sollte. Moprolol') is an interesting P-blocker commercialized in Italy as Omeral, being of clinical

We describe in this paper the synthesis and a preliminary pharmacological evaluation of the p-adrenergic blocking activity of the thiophene isoster of Moprolol Id. The pharmacological profile of this compound is completed with the study of its in vifro antiplatelet aggregation activity.