## Abstract Nitrooxymethyl‐substituted derivatives of Rofecoxib were synthesized and tested for their cyclooxygenase (COX)‐inhibiting activity in whole human blood, vasodilator potency on rat aorta strips, and for their capacity of inhibiting platelet aggregation of human platelet‐rich plasma. The
Nitrooxymethyl-Substituted Analogues of Celecoxib: Synthesis and Pharmacological Characterization
✍ Scribed by Donatella Boschi; Loretta Lazzarato; Barbara Rolando; Andrea Filieri; Clara Cena; Antonella Di Stilo; Roberta Fruttero; Alberto Gasco
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 198 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1612-1872
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Synthesis and Pharmacological Evaluation of Triflate-Substituted Analogues of Clozapine: Identification of a Novel Atypical Neuroleptic. -Evaluation of triflate derivatives of clozapine and iso-clozapine shows that compound (I) is at least three times more potent than clozapine itself, indicating t
The syntheses of the thiophenic analogue of Moprolol (Id) and of its related compound l a are described. From a preliminary pharmacological evaluation compound Id seems worthy of further studies due to its notable P-blocking activity and its remarkable anti-platelet aggregation action. ## Synthese
## Abstract In search of potent 1__H__‐1,2,4‐triazole derivatives with improving antifungal activity, a class of novel ferrocene–triadimenol analogues was synthesized and their biological potential evaluated. Screening data revealed that these new derivatives did not have the antifungal activities