SequentiuZ reactions of 2-chZoro-or 2-bromo-3-tert-butyloxirane with p-chloropheno-2ate nnd tken uitk sodiwn triasolate Zead in two stereocontro2led ste.ps to tkreo-Triadimenol; by inverse addition of the tuo nucleophiles the erythro-isomer is obtained. l-(4-Chlorophenoxy)-3,3-dimethyl-1-(l,Z,4-tria
Synthesis of isoquinoline alkaloids. Total synthesis of (±)-tetrahydroescholamine and its (±)-threo- and (±)-erythro-α-hydroxy analogs
✍ Scribed by Rozwadowska, Maria D. ;Matecka, Dorota ;Brózda, Danuta
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 288 KB
- Volume
- 1991
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Abstract
The studied tetrahydroisoquinolines 1, 2 and 3 were synthesized from a common intermediate 6, which was prepared by addition of the lithium salt of dithiane 5 to hydrastinine chloride (4).
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