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The first total synthesis of iPF4α-VI and its deuterated analog

✍ Scribed by Seongjin Kim; John A. Lawson; Domenico Praticò; Garret A. FitzGerald; Joshua Rokach

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 119 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00398-2

No coin nor oath required. For personal study only.

✦ Synopsis

The total and stereospecific syntheses of iPF 4a -VI and d 4 -iPF 4a -VI have been accomplished. iPF 4a -VI is a docosahexanenoic acid (DHA)-derived isoprostane. DHA is the most abundant polyunsaturated fatty acid in the brain. Different synthetic designs have been used for the two syntheses. In the d 4 -iPF 4a -VI design, the deuterated part of the molecule was introduced last in the synthesis.

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