Synthesis of Heterocycles Using Zirconium-Catalyzed Asymmetric Diene Cyclization
β Scribed by Yamaura, Yousuke; Hyakutake, Masaru; Mori, Miwako
- Book ID
- 126296947
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 61 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
Cyclization of diene 2a using (S)-(EBTHI)ZrB1NOL (1) (10 mol %) and BuNIgCI in THF upon heating gave cyclopentane derivative tr~s-3a with 99% ee and cis-3a with 86% ee in 69% and 31% yields, respectively. In a similar manner, diene 10 gave cyclopentane derivative cis-ll with 94% ee in 81% yield as a
Enantioselective Synthesis of Cyclopentane Derivatives Using Zirconium-Catalyzed Asymmetric Cyclization. -The cyclization of dienes such as (I), (IV), and (VI) in the presence of Bu-MgCl and a chiral Zr-catalyst is studied. Optically active highly substituted cyclopentanes are obtained in good to h
R,S)-BnBpY-H (BnBp={(OC 10 H 6 C 10 H 6 O)Si(C 5 H 2 -2-SiMe 3 -4-CMe 3 ) 2 }) is an effective catalyst for the cyclization-hydrosilylation of a,v-dienes. The cyclization of 1,5-hexadienes and 1,6-heptadienes results in the formation of five-and six-membered rings, respectively, with low to moderate