Novel Synthesis of Heterocycles Using Zirconium-Catalyzed Diene Cyclization
โ Scribed by Uesaka, Noriaki; Mori, Miwako; Okamura, Kimio; Date, Tadamasa
- Book ID
- 126126004
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 716 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
Cyclization of diene 2a using (S)-(EBTHI)ZrB1NOL (1) (10 mol %) and BuNIgCI in THF upon heating gave cyclopentane derivative tr~s-3a with 99% ee and cis-3a with 86% ee in 69% and 31% yields, respectively. In a similar manner, diene 10 gave cyclopentane derivative cis-ll with 94% ee in 81% yield as a
Enantioselective Synthesis of Cyclopentane Derivatives Using Zirconium-Catalyzed Asymmetric Cyclization. -The cyclization of dienes such as (I), (IV), and (VI) in the presence of Bu-MgCl and a chiral Zr-catalyst is studied. Optically active highly substituted cyclopentanes are obtained in good to h