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Synthesis of Gd-DTPA-cholesterol: a new lipophilic gadolinium complex as a potential MRI contrast agent

✍ Scribed by Luciano Lattuada; Giovanna Lux

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
196 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

A straightforward and efficient synthesis of Gd-DTPA-cholesterol is reported. This new lipophilic gadolinium complex can be easily incorporated into mixed micelles in order to achieve MRI contrast agents with increased relaxivity. These supramolecular systems can find potential application in magnetic resonance angiography (MRA).

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