A straightforward and efficient synthesis of Gd-DTPA-cholesterol is reported. This new lipophilic gadolinium complex can be easily incorporated into mixed micelles in order to achieve MRI contrast agents with increased relaxivity. These supramolecular systems can find potential application in magnet
Synthesis of the Gd(III) complex with a tetrazole-armed macrocyclic ligand as a potential MRI contrast agent
β Scribed by Silvio Aime; Giancarlo Cravotto; Simonetta Geninatti Crich; Giovanni B. Giovenzana; Marinella Ferrari; Giovanni Palmisano; Massimo Sisti
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 100 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
We report the synthesis and the properties of the Gd(III) complex with 4 (H 4 dotetra), a novel mixed pendant-arm macrocyclic ligand embodying a tetrazole subunit in a N 5 O 3 donor set as a potential magnetic resonance imaging (MRI) contrast agent.
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