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Effect of a mesitylene-based ligand cap on the relaxometric properties of Gd(III) hydroxypyridonate MRI contrast agents

✍ Scribed by Eric J. Werner; Mauro Botta; Silvio Aime; Kenneth N. Raymond

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
481 KB
Volume
4
Category
Article
ISSN
1555-4309

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✦ Synopsis

Abstract

A series of new Gd(III) hydroxypyridonate complexes featuring a mesitylene (ME)‐derived ligand cap has been prepared. Relaxometric characterization reveals that the complexes tend to form large aggregates in solution with slow tumbling rates, as estimated from NMRD analysis, and unique pH‐dependent relaxivities. The solution behavior and relaxometric properties are compared with those observed for analogous TREN‐capped compounds, and the potential for use of these new ME‐capped complexes as pH‐responsive MRI contrast agents is explored. Copyright © 2009 John Wiley & Sons, Ltd.

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