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Sulfonamide-Functionalized Gadolinium DTPA Complexes as Possible Contrast Agents for MRI: A Relaxometric Investigation

✍ Scribed by Pier Lucio Anelli; Ivano Bertini; Marco Fragai; Luciano Lattuada; Claudio Luchinat; Giacomo Parigi

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 253 KB
Volume: 2000
Category: Article
ISSN: 1434-1948
DOI: 10.1002/(sici)1099-0682(200004)2000:4<625::aid-ejic625>3.0.co;2-2

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✦ Synopsis

A novel Gd-DTPA derivative with a built-in sulfonamide (SA) was synthesized as a contrast agent for MRI. The complex was designed to selectively target the enzyme carbonic anhydrase. It is shown that the longitudinal relaxation rates of aqueous solutions of Gd-DTPA-SA in the presence of carbonic anhydrase increase significantly. The binding constant is determined to be 15,000 ± 5,000 M -1 . This value ensures substantial formation of the carbonic anhydrase adduct at imaging concentrations of Gd-DTPA-SA. The complex interacts

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