Sulfonamide-Functionalized Gadolinium DT
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Pier Lucio Anelli; Ivano Bertini; Marco Fragai; Luciano Lattuada; Claudio Luchin
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Article
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2000
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John Wiley and Sons
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English
⚖ 253 KB
A novel Gd-DTPA derivative with a built-in sulfonamide (SA) was synthesized as a contrast agent for MRI. The complex was designed to selectively target the enzyme carbonic anhydrase. It is shown that the longitudinal relaxation rates of aqueous solutions of Gd-DTPA-SA in the presence of carbonic anh