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Synthesis of enantiomerically pure (R)- and (S)-3-methyl-2-cyclopenten-1-ol

✍ Scribed by Xiaoming Zhou; Pierre J. De Clercq; Jacek Gawronski


Book ID
108036303
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
142 KB
Volume
6
Category
Article
ISSN
0957-4166

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Addition of molecular fluorine to cis-2-cyclopentene-1 ,Cdiol gave the c&anti adduct stereoselectively. This meso diol was dissymmetrized by means of acetylation under lipase catalysis to afford the monoacetate with a high enatiomeric purity. Oxidation of the monoacetate followed by elimination of h