✦ LIBER ✦

Glutamate transporter blockers: enantiomerically pure (2S,3S)- and (2S,3R)-3-methyl glutamic acids

✍ Scribed by J. Wehbe; V. Rolland; M.L. Roumestant; J. Martinez

Book ID: 104359730
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 144 KB
Volume: 14
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(03)00127-7

No coin nor oath required. For personal study only.

✦ Synopsis

A short four-step synthesis of (2S,3R)-and (2S,3S)-3-methyl glutamic acids is reported; the (2S,3R) isomer presented a significant inhibitory effect on glutamate transport.

📜 SIMILAR VOLUMES

Assymetric synthesis of (2S,3R)- and (2S

Assymetric synthesis of (2S,3R)- and (2S,3S)-[2-13C;3-2H] glutamic acid

✍ Kosuke Okuma; Akira M. Ono; Seiji Tsuchiya; Makoto Oba; Kozaburo Nishiyama; Masa 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 358 KB

Synthesis of enantiomerically pure (R)-

Synthesis of enantiomerically pure (R)- and (S)-3-methyl-2-cyclopenten-1-ol

✍ Xiaoming Zhou; Pierre J. De Clercq; Jacek Gawronski 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 142 KB

Asymmetric synthesis of enantiomerically

Asymmetric synthesis of enantiomerically pure (2S,1′S,2′S,3′R)-phenylcarboxycyclopropylglycine (PCCG-4): a potent and selective ligand at group II metabotropic glutamate receptors

✍ Maura Marinozzi; Benedetto Natalini; Gabriele Costantino; Pierre Tijskens; Chris 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 179 KB

Stereochemically defined C-substituted g

Stereochemically defined C-substituted glutamic acids and their derivatives. 1. An efficient asymmetric synthesis of (2S,3S)-3-methyl- and -3-trifluoromethylpyroglutamic acids

✍ Vadim A Soloshonok; Chaozhong Cai; Victor J Hruby; Luc Van Meervelt; Nikolai Mis 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 941 KB

Asymmetric synthesis of (2S,3S)- and (2S

Asymmetric synthesis of (2S,3S)- and (2S,3R)-3-prolinomethionines: 3-methylsulfanylmethyl-pyrrolidine-2-carboxylic acids

✍ Philippe Karoyan; Gérard Chassaing 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 547 KB

The synthesis of 3-prolinomethionine can be easily achieved in a diastereoselective and enantioselective way via zinc-enolate cyclisation. After transmetallation by CuCN.2LiCI, the zinc--copper derivative was reacted with S-methyl methanesulfonothioate leading in a "one-pot" procedure, to N-(0t-meth

Short asymmetric synthesis of (2S,3S)- a

Short asymmetric synthesis of (2S,3S)- and (2S,3R)-3-prolinoglutamic acids: 2-carboxy-3-pyrrolidine-acetic acids (CPAA)

✍ Philippe Karoyan; Gérard Chassaing 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 63 KB

The asymmetric synthesis of both cis and trans 3-prolinoglutamic acids can be easily achieved in a diastereoselective and enantioselective way via the amino-zinc-enolate cyclisation.